重症肌无力中抗酸溶性骨骼肌抗原抗体的酶联免疫吸附测定
An enzyme-linked immunosorbent assay for antibodies against acid soluble skeletal muscle antigen in myasthenia gravis.
作者信息
Annamma M, Sarada C, Radhakrishnan V V
机构信息
Department of Pathology, Sree Chitra Tirunal Institute for Medical Science and Technology, Thiruvananthapuram, Kerala State, India.
出版信息
Acta Neurol Scand. 1999 Sep;100(3):175-7. doi: 10.1111/j.1600-0404.1999.tb00734.x.
An enzyme-linked immunosorbent assay (ELISA) system has been developed for measuring serum antibodies against citric-acid extract of human skeletal muscles. With this assay, 80% of myasthenia patients with thymoma gave positive results. No sera from patients with neurological diseases other than myasthenia gravis (MG) gave positive results. The result of this study indicates that the ELISA system is useful as an adjunct for the diagnosis of MG particularly in the patients associated with thymoma and that the ELISA method can also be used as a prognostic marker following thymectomy in patients with MG.
已开发出一种酶联免疫吸附测定（ELISA）系统，用于检测人骨骼肌柠檬酸提取物的血清抗体。通过该测定，80%患有胸腺瘤的重症肌无力患者检测结果呈阳性。除重症肌无力（MG）外，其他神经系统疾病患者的血清检测结果均为阴性。本研究结果表明，ELISA系统可用作MG诊断的辅助手段，特别是对于伴有胸腺瘤的患者，并且ELISA方法也可用作MG患者胸腺切除术后的预后标志物。
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