Semisynthesis and cytotoxicity of styryl-lactone derivatives.

作者信息

Bermejo A, Léonce S, Cabedo N, Andreu I, Caignard D H, Atassi G, Cortes D

机构信息

Departamento de Farmacología, Farmacognosia y Farmacodinamia, Facultad de Farmacia, Universidad de Valencia, 46100 Burjassot, Valencia, Spain.

出版信息

J Nat Prod. 1999 Aug;62(8):1106-9. doi: 10.1021/np990089q.

DOI:10.1021/np990089q

PMID:10479313

Abstract

The cytotoxicity and the cell-cycle action of altholactone (1), goniofufurone (2), and eight altholactone derivatives (5-12), were determined in vitro on L-1210 cells. Semisyntheses and structure-activity relationships of these compounds are described. The results of this study suggest that the cytotoxicity of altholactone (1), 11-nitro-altholactone (8), and 7-chloro-6,7-dihydroaltholactone (10) is due to the accumulation of the cells in the G2 + M phase of the cell cycle.

摘要