由D-木糖发散合成细胞毒性苯乙烯基内酯。(+)-厚壳内酯C的首次全合成。

Divergent synthesis of cytotoxic styryl lactones from D-xylose. The first total synthesis of (+)-crassalactone C.

作者信息

Popsavin Velimir, Benedeković Goran, Srećo Bojana, Popsavin Mirjana, Francuz Jovana, Kojić Vesna, Bogdanović Gordana

机构信息

Department of Chemistry, Faculty of Sciences, University of Novi Sad, Trg D. Obradovića 3, 21000 Novi Sad, Serbia.

出版信息

Org Lett. 2007 Oct 11;9(21):4235-8. doi: 10.1021/ol701734s. Epub 2007 Sep 15.

DOI:10.1021/ol701734s

PMID:17867695

Abstract

A new divergent approach to (+)-goniofufurone (1) and 7-epi-(+)-goniofufurone (2), as well as the first total synthesis of crassalactone C (3), has been achieved starting from D-xylose. In a preliminary bioassay, all three natural products 1, 2, and 3 showed remarkable in vitro antiproliferative activities against K562, Raji, and HeLa neoplastic cell lines.

摘要

已实现了一种从D-木糖出发合成(+)-戈尼呋喃酮(1)和7-表-(+)-戈尼呋喃酮(2)的新的发散式方法，以及首次全合成厚壳内酯C(3)。在初步生物测定中，所有三种天然产物1、2和3对K562、Raji和HeLa肿瘤细胞系均显示出显著的体外抗增殖活性。