Biswas S, Talukder G, Sharma A
Vivekananda Institute of Medical Sciences, 99 Sarat Bose Road, Calcutta 700 026, India.
Phytother Res. 1999 Sep;13(6):513-6. doi: 10.1002/(sici)1099-1573(199909)13:6<513::aid-ptr525>3.0.co;2-6.
Dietary administration of a crude aqueous extract of Emblica officinalis Gaertn. fruit reduced significantly the cytotoxic effects of sodium arsenite administered orally. The crude extract (685 mg/kg bw) was given daily by gavaging to age and sex matched laboratory bread Swiss albino mice for 7 and 14 days, followed by a single dose of sodium arsenite (2.5 mg/kg bw = 1/10 of LD(50)). The animals were killed after 24 h and chromosome preparations made following a schedule of colchicine-fixative-air drying-Giemsa. The endpoints screened were chromosomal aberrations and damaged cells. The crude extract reduced arsenic damage bringing the cells almost to the normal level.
余甘子果实粗水提取物的膳食给药显著降低了口服亚砷酸钠的细胞毒性作用。将粗提取物（685毫克/千克体重）每天通过灌胃给予年龄和性别匹配的实验室饲养的瑞士白化小鼠，持续7天和14天，随后给予单剂量的亚砷酸钠（2.5毫克/千克体重 = LD(50)的1/10）。24小时后处死动物，并按照秋水仙碱-固定剂-空气干燥-吉姆萨染色的程序制备染色体。筛选的终点是染色体畸变和受损细胞。粗提取物减少了砷的损伤，使细胞几乎恢复到正常水平。
