阿育吠陀阿玛拉吉药的免疫调节活性：一项实验评估。
Immunomodulatory activity of Āmalaki Rasāyana: An experimental evaluation.
作者信息
Rajani Jignesh, Ashok B K, Patgiri B J, Prajapati P K, Ravishankar B
机构信息
Department of Rasashastra and Bhaishajya Kalpana Including Drug Research, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India.
出版信息
Anc Sci Life. 2012 Oct;32(2):93-8. doi: 10.4103/0257-7941.118546.
BACKGROUND
Ayurvedic system of medicine holds a number of drugs that improves the immunity. Āmalaki (Emblica officinalis) is one such drug. Researches with crude extracts of Āmalaki have proven the antioxidant and immunomodulatory activities. But, works on Āmalaki Rasāyana are not found reported.
AIMS
Considering this, two samples of Āmalaki Rasāyana (AR7 and AR21) were studied to evaluate comparative immunomodulatory activity against the cyclophosphamide immunosuppression in rats.
MATERIALS AND METHODS
Test drugs were prepared by following classical guidelines. Wistar strain albino rats of either sex were used in the study.
STATISTICAL ANALYSIS
For comparison of data from cyclophosphamide control group with remaining cyclophosphamide plus test drug administered groups one way ANOVA with Dunnett's multiple t-test (DMTT) was employed.
RESULTS AND CONCLUSIONS
Āmalaki Rasāyana possesses significant immunostimulant activity and moderate cytoprotective activity. AR21 was found to have better activity profile in terms of both immunostimulant as well as cytoprotective activity.
背景
阿育吠陀医学体系中有多种能增强免疫力的药物。余甘子（印度醋栗）就是其中一种。对余甘子粗提物的研究已证实其具有抗氧化和免疫调节活性。但是，尚未发现有关余甘子药 rasāyana 的研究报道。
目的
鉴于此，对两种余甘子药 rasāyana 样品（AR7 和 AR21）进行研究，以评估其对大鼠环磷酰胺诱导的免疫抑制的比较免疫调节活性。
材料与方法
按照经典方法制备受试药物。选用 Wistar 品系的白化大鼠，雌雄不限。
统计分析
为比较环磷酰胺对照组与其余环磷酰胺加受试药物给药组的数据，采用单因素方差分析和 Dunnett 多重 t 检验（DMTT）。
结果与结论
余甘子药 rasāyana 具有显著的免疫刺激活性和适度的细胞保护活性。就免疫刺激和细胞保护活性而言，发现 AR21 具有更好的活性表现。
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