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[肺复张性肺水肿。两例病例描述及其处理观察]

[Pulmonary re-expansion edema. Description of two cases and observations about its management].

作者信息

Biffoli F, Lenzi G, Melis P, Piacentino V

机构信息

UO Anestesia e Rianimazione, ASL 2, Lucca.

出版信息

Minerva Anestesiol. 1999 Jul-Aug;65(7-8):575-9.

PMID:10479846
Abstract

Two cases of Reexpansion pulmonary edema (RPE), an uncommon complication of the treatment of chronic lung collapse secondary to pneumothorax or pleural effusion, are described. RPE is generally unilateral and occurs when the lung is rapidly reexpanded by active evacuation of large amounts of air or fluid. Nevertheless, both cases observed confirm that RPE can be seen when the pulmonary collapse is of short duration and the lung is reexpanded without suction. The pathogenesis of RPE is still unclear and is probably multifactorial. Implicated in the etiological process of RPE are chronicity of collapse, technique of reexpansion, increased pulmonary vascular permeability, airway obstruction, loss of surfactant, and pulmonary artery pressure changes. In the observed cases RPE appeared unexpectedly and dramatically, which is typical of the condition. The edema progressed for 24-48 hours, although it may persist for 4-5 days. Therapy was supportive and proportional to the severity of the clinical picture. Both needed mechanical ventilation, while only in case 1 was a hemodynamic support applied. Since the outcome is still fatal in 20% of cases, physicians treating chronic lung collapse must be aware of the possible causes and try to prevent the occurrence of this complication.

摘要

本文描述了两例复张性肺水肿(RPE),这是气胸或胸腔积液继发慢性肺萎陷治疗中一种罕见的并发症。RPE通常为单侧,发生于通过主动排出大量气体或液体使肺迅速复张时。然而,观察到的这两例均证实,当肺萎陷持续时间短且肺在无负压吸引情况下复张时,也可出现RPE。RPE的发病机制仍不清楚,可能是多因素的。RPE的病因学过程涉及萎陷的慢性化、复张技术、肺血管通透性增加、气道阻塞、表面活性物质丧失以及肺动脉压力变化。在观察到的病例中,RPE意外且显著地出现,这是该病症的典型表现。水肿持续24 - 48小时,尽管可能持续4 - 5天。治疗以支持治疗为主,与临床表现的严重程度相称。两例均需要机械通气,而仅病例1给予了血流动力学支持。由于20%的病例结局仍为死亡,治疗慢性肺萎陷的医生必须了解可能的病因,并努力预防这种并发症的发生。

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