Nitta K, Uchida K, Kimata N, Honda K, Horita S, Hayashi T, Ishizuka T, Kobayashi H, Kawashima A, Yumura W, Nihei H
Department of Medicine, Kidney Center, Tokyo Women's Medical University, Japan.
Clin Nephrol. 1999 Aug;52(2):76-82.
To investigate the serum levels of vascular endothelial growth factor (VEGF) in human crescentic glomerulonephritis (CRGN).
The serum VEGF levels in CRGN patients were compared with those in healthy subjects and in various types of glomerulonephritis. In addition, we investigated the relationship between serum VEGF levels and creatinine levels (Scr) and pathological parameters.
The serum VEGF levels of the CRGN patients were significantly higher than in the healthy subjects and patients with MCNS, IgAN, and FGS. No correlation was found between serum VEGF levels and Scr in the RPGN patients. The serum VEGF levels in 6 CRGN patients had significantly decreased after 6 months of corticosteroid therapy. Moreover, there was a significant correlation between the serum VEGF levels and the crescent frequency or the grade of interstitial injury, and the rates of glomerular infiltration by macrophages.
In the CRGN patients, severe glomerular and interstitial damages would result in increased serum VEGF levels and corticosteroid therapy may exert its efficacy through reduction of serum VEGF levels.
研究人新月体性肾小球肾炎（CRGN）患者血清血管内皮生长因子（VEGF）水平。
比较CRGN患者与健康受试者以及各类肾小球肾炎患者的血清VEGF水平。此外，我们还研究了血清VEGF水平与肌酐水平（Scr）及病理参数之间的关系。
CRGN患者的血清VEGF水平显著高于健康受试者以及微小病变肾病（MCNS）、IgA肾病（IgAN）和局灶节段性肾小球硬化（FGS）患者。RPGN患者的血清VEGF水平与Scr之间未发现相关性。6例CRGN患者在接受皮质类固醇治疗6个月后血清VEGF水平显著下降。此外，血清VEGF水平与新月体频率或间质损伤分级以及巨噬细胞肾小球浸润率之间存在显著相关性。
在CRGN患者中，严重的肾小球和间质损伤会导致血清VEGF水平升高，皮质类固醇治疗可能通过降低血清VEGF水平发挥其疗效。
