Malin R, Rantalaiho V, Huang X H, Wirta O, Pasternack A, Leinonen J S, Alho H, Jokela H, Koivula T, Tanaka T, Okada K, Ochi H, Toyokuni S, Lehtimäki T
Department of Clinical Chemistry, Tampere University Hospital, Finland.
Hum Genet. 1999 Jul-Aug;105(1-2):179-80. doi: 10.1007/s004399900074.
The paraoxonase enzyme (PON) gene polymorphism causes a change of methionine (M-allele) to leucine (L-allele). PON may reduce low density lipoprotein oxidation and prevent atherosclerosis. Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a sensitive index of oxidative DNA damage. We have studied the association between the PON genotypes and the urinary excretion of 8-OHdG. The study population consisted of 93 Finnish type 2 diabetes patients and 106 non-diabetic control subjects. The 24-h excretion of 8-OHdG was significantly higher in diabetic patients than in control subjects (P < 0.001). In control subjects, the ratio of the 8-OHdG/glomerular filtration rate increased in order of genotype from MM to ML to LL (P < 0.0412). These results suggest that lipid peroxidation may have an effect on DNA oxidation.
对氧磷酶（PON）基因多态性导致甲硫氨酸（M等位基因）变为亮氨酸（L等位基因）。对氧磷酶可能会减少低密度脂蛋白氧化并预防动脉粥样硬化。尿8-羟基-2'-脱氧鸟苷（8-OHdG）是氧化性DNA损伤的一个敏感指标。我们研究了对氧磷酶基因型与8-OHdG尿排泄之间的关联。研究人群包括93名芬兰2型糖尿病患者和106名非糖尿病对照者。糖尿病患者的8-OHdG 24小时排泄量显著高于对照者（P<0.001）。在对照者中，8-OHdG/肾小球滤过率的比值按基因型从MM到ML再到LL依次升高（P<0.0412）。这些结果表明脂质过氧化可能对DNA氧化有影响。
