Holthausen E A, Wiersma D, Knegtering R H, Van den Bosch R J
Department of Psychiatry, University Hospital Groningen, Netherlands.
Schizophr Res. 1999 Aug 23;39(1):65-71. doi: 10.1016/s0920-9964(99)00020-1.
The cognitive correlates of five symptom dimensions based on PANSS ratings were examined in a group of 50 recent onset psychotic patients, using both objective and subjective cognitive measures. We were particularly interested in the depression dimension, since it has not been studied extensively thus far. The depression dimension showed a high number of correlations with both objective and subjective cognitive measures, such as problems with simple and divided attention, psychomotor slowing and subjectively experienced distractibility, overload and diminished attentional control. The other dimensions, including negative symptoms, have less cognitive correlates. It is possible that previous studies based on a three-dimensional model confounded correlates of negative symptoms with correlates of depressive symptoms. The results of this study suggest the need for more research into the mechanisms underlying the relationship between depressive symptoms and cognitive functioning in schizophrenia, and that patients with depressive symptoms are less efficient in information processing, but can compensate by investing more mental effort. Because subjective cognitive measures were related to mental effort in previous research, they can be a useful tool in future research.
在一组50名近期发病的精神病患者中，使用客观和主观认知测量方法，研究了基于阳性和阴性症状量表（PANSS）评分的五个症状维度的认知相关性。我们对抑郁维度特别感兴趣，因为到目前为止它尚未得到广泛研究。抑郁维度与客观和主观认知测量方法都有大量相关性，如简单和分散注意力方面的问题、精神运动迟缓以及主观体验到的注意力分散、负荷过重和注意力控制减弱。包括阴性症状在内的其他维度，认知相关性较少。基于三维模型的先前研究可能将阴性症状的相关性与抑郁症状的相关性混淆了。本研究结果表明，需要对精神分裂症中抑郁症状与认知功能之间关系的潜在机制进行更多研究，并且有抑郁症状的患者在信息处理方面效率较低，但可以通过投入更多的心理努力来进行补偿。由于主观认知测量方法在先前研究中与心理努力相关，它们可以成为未来研究中的有用工具。
