Xu B, Pekkanen J, Järvelin M R, Olsen P, Hartikainen A L
Unit of Environmental Epidemiology, National Public Health Institute, Kuopio, Finland.
Int J Epidemiol. 1999 Aug;28(4):723-7. doi: 10.1093/ije/28.4.723.
Previous studies have suggested that asthma phenotype could probably be programmed before birth. The current study examined the impact of maternal vaginitis and febrile infections during pregnancy on the subsequent development of asthma among children.
The analyses were based on 8088 children from the northern Finland birth cohort, 1985-1986.
The prevalence of asthma at age 7 was 3.5%. Children had a higher risk of asthma if their mothers experienced vaginitis and febrile infections during pregnancy, odds ratio (OR) = 1.41, (95% CI: 1.08-1.84) and 1.65 (95% CI: 1.25-2.18), respectively, after adjusting for other covariates. There was a clear time trend in risk of childhood asthma corresponding to the timing of maternal febrile infections in pregnancy. The adjusted OR for the first, second and third trimesters were 2.08 (95% CI: 1.13-3.82), 1.73 (95% CI: 1.09-2.75) and 1.44 (95% CI: 0.97-2.15), respectively. Maternal history of allergic diseases, birthweight <2500 g and male gender also seemed to be risk factors for childhood asthma.
Our results suggest that further investigation of the relation of maternal infections during pregnancy to asthma among children seems warranted.
先前的研究表明哮喘表型可能在出生前就已形成。本研究调查了孕期母亲患阴道炎和发热性感染对儿童随后患哮喘的影响。
分析基于1985 - 1986年芬兰北部出生队列中的8088名儿童。
7岁时哮喘患病率为3.5%。如果母亲在孕期经历阴道炎和发热性感染，其子女患哮喘的风险更高，在调整其他协变量后，比值比（OR）分别为1.41（95%可信区间：1.08 - 1.84）和1.65（95%可信区间：1.25 - 2.18）。儿童哮喘风险存在明显的时间趋势，与母亲孕期发热性感染的时间相对应。孕早期、中期和晚期调整后的OR分别为2.08（95%可信区间：1.13 - 3.82）、1.73（95%可信区间：1.09 - 2.75）和1.44（95%可信区间：0.97 - 2.15）。母亲的过敏性疾病史、出生体重<2500 g和男性性别似乎也是儿童哮喘的危险因素。
我们的结果表明，有必要进一步研究孕期母亲感染与儿童哮喘之间的关系。
