Haddad B, Sibai B M
Department of Obstetrics and Gynecology, University of Tennessee, Memphis 38103, USA.
Ann Med. 1999 Aug;31(4):246-52. doi: 10.3109/07853899908995887.
Pregnancies in women with chronic hypertension are at increased risk of superimposed pre-eclampsia, abruptio placentae, fetal growth retardation and prematurity. The frequencies of these complications are increased in those women who have high-risk chronic hypertension, ie severe hypertension or pre-existing cardiovascular or renal diseases, as well as in those with target organ damage. Such women should receive antihypertensive therapy and close management to improve maternal and fetal outcome. In women with low-risk chronic hypertension, antihypertensive treatments do not improve pregnancy outcome. Prophylactic low-dose acetylsalicylic acid treatment does not reduce the frequency of superimposed pre-eclampsia nor does it improve perinatal outcome in these pregnancies.
患有慢性高血压的女性怀孕时，发生子痫前期、胎盘早剥、胎儿生长受限和早产的风险会增加。这些并发症的发生率在患有高危慢性高血压的女性中有所增加，即重度高血压或已存在心血管或肾脏疾病的女性，以及有靶器官损害的女性。这类女性应接受抗高血压治疗和密切管理，以改善母婴结局。对于患有低危慢性高血压的女性，抗高血压治疗并不能改善妊娠结局。预防性低剂量阿司匹林治疗既不能降低子痫前期的发生率，也不能改善这些妊娠的围产期结局。
