双轻链病：一例报告
Double light-chain disease: a case report.
作者信息
Dalal F R, Winsten S
出版信息
Clin Chem. 1979 Jan;25(1):190-2.
PMID:104808
Abstract
A patient with massive proteinuria was discovered to have double light-chain disease. Immunological studies demonstrated monoclonal light chains of both the lambda and kappa type in urine. The light chains were separate and distinct and were not found to be a part of any of the whole molecule immunoglobulins such as IgG, IgM, IgA, IgD, or IgE. Uniqueness of the proteins was confirmed by column chromatography. Clinical studies showed that the patient had multiple myeloma.
摘要
一名大量蛋白尿患者被发现患有双轻链病。免疫学研究表明尿液中存在λ型和κ型单克隆轻链。这些轻链是分离且独特的，未发现它们是任何完整分子免疫球蛋白（如IgG、IgM、IgA、IgD或IgE）的一部分。通过柱色谱法证实了这些蛋白质的独特性。临床研究表明该患者患有多发性骨髓瘤。
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