Arao H, Obata M, Shimada T, Hagisawa S
Oita Medical University, School of Nursing.
J Tissue Viability. 1998 Jul;8(3):17-23. doi: 10.1016/s0965-206x(98)80042-9.
Mechanisms of skin break down in the development of human pressure sores are still unclear. This study was undertaken to clarify the morphological characteristics of the dermal papillae in the skin associated with pressure sores. Skin tissues were excised from the sacrum of a Japanese subject post mortem, where a superficial pressure sore had developed. Light microscopic and transmission and scanning electron microscopic examinations were performed. It was found that the atrophic, irregular contour and alignment of the dermal papillae were characteristic of the boundary area between healthy and damaged areas. In addition, a relatively dense network of collagen fibres in the papillary layer of the boundary area was observed when compared with the healthy area. These findings suggest that the morphological changes of the papillae observed in the boundary area affect microcirculation, impairing tissue viability by inhibiting nutritive blood supply and by accumulating metabolic byproducts which predispose to tissue damage.
人类压疮形成过程中皮肤破损的机制仍不清楚。本研究旨在阐明与压疮相关皮肤中真皮乳头的形态特征。从一名死后的日本受试者骶骨处切除皮肤组织，该部位出现了浅表压疮。进行了光镜、透射电镜和扫描电镜检查。结果发现，真皮乳头萎缩、轮廓不规则且排列紊乱是健康区域与受损区域边界区域的特征。此外，与健康区域相比，边界区域乳头层中胶原纤维网络相对密集。这些发现表明，在边界区域观察到的乳头形态变化会影响微循环，通过抑制营养血液供应和积累代谢副产物来损害组织活力，从而易导致组织损伤。
