Miralles R, Gerrish P J, Moya A, Elena S F
Institut Cavanilles de Biodiversitat i Biología Evolutiva and Departament de Genètica, Universitat de València, Apartado 22085, 46071 València, Spain.
Science. 1999 Sep 10;285(5434):1745-7. doi: 10.1126/science.285.5434.1745.
In asexual populations, beneficial mutations that occur in different lineages compete with one another. This phenomenon, known as clonal interference, ensures that those beneficial mutations that do achieve fixation are of large effect. Clonal interference also increases the time between fixations, thereby slowing the adaptation of asexual populations. The effects of clonal interference were measured in the asexual RNA virus vesicular stomatitis virus; rates and average effects of beneficial mutations were quantified.
在无性繁殖群体中，不同谱系中出现的有益突变会相互竞争。这种现象被称为克隆干扰，它确保那些真正实现固定的有益突变具有较大的效应。克隆干扰还会增加固定之间的时间间隔，从而减缓无性繁殖群体的适应速度。在无性RNA病毒水疱性口炎病毒中测量了克隆干扰的影响；对有益突变的发生率和平均效应进行了量化。
