[阿尔茨海默病轻、中度阶段脑单光子发射计算机断层扫描与神经心理学评估之间的相关性]

[Correlations between brain SPECT and neuropsychology assessments in mild and moderate stages of Alzheimer's disease].

作者信息

Arbizu J, Larumbe R, Gámez C, Martí J, Martínez-Lage J, Richter J

机构信息

Servicio de Medicina Nuclear, Clínica Universitaria de Navarra, Pamplona, Navarra, 31008, España.

出版信息

Rev Esp Med Nucl. 1999 Aug;18(4):252-60.

PMID:10481106

Abstract

UNLABELLED

Thirty-four patients with a probable Alzheimer's Disease (AD) (mild AD = 16; moderate AD = 18) and 12 matched controls were evaluated using semiquantitative SPECT-99mTc-HMPAO and neuropsychological tests (CERAD).

RESULTS

Both temporal hypoperfusion (p < 0.01) and memory tests (p < 0.001) made it possible to differentiate the controls from mild AD patients. In these patients, significant correlations (p < 0.05) were also found between: 1) delayed recall test/temporal hypoperfusion, 2) learning memory test/temporoparietal and frontal hypoperfusion and 3) visual constructive praxis/posterior temporal hypoperfusion. In contrast to mild AD, moderate AD patients showed higher temporal (p < 0.01) parietal and frontal (p < 0.05) hypoperfusion along with worsening of praxis (p < 0.001) and memory tests (p < 0.05).

CONCLUSIONS

SPECT imaging and neuropsychology evaluation can distinguish controls from AD patients with mild an moderate grades of dementia, showing a strong correlation from the early stages of AD.

摘要

未标记

使用半定量单光子发射计算机断层扫描（SPECT）-99m锝-六甲基丙二胺肟（HMPAO）和神经心理学测试（CERAD）对34例可能患有阿尔茨海默病（AD）的患者（轻度AD = 16例；中度AD = 18例）和12例匹配的对照者进行评估。

结果

颞叶灌注不足（p < 0.01）和记忆测试（p < 0.001）均能够区分对照者与轻度AD患者。在这些患者中，还发现以下各项之间存在显著相关性（p < 0.05）：1）延迟回忆测试/颞叶灌注不足；2）学习记忆测试/颞顶叶和额叶灌注不足；3）视觉构建操作/颞叶后部灌注不足。与轻度AD不同，中度AD患者表现出更高程度的颞叶（p < 0.01）、顶叶（p < 0.05）和额叶（p < 0.05）灌注不足，同时操作能力（p < 0.001）和记忆测试（p < 0.05）恶化。