Song In-Uk, Chung Yong-An, Chung Sung-Woo, Jeong Jaeseung
Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Dement Geriatr Cogn Disord. 2014;37(5-6):276-85. doi: 10.1159/000357128. Epub 2013 Dec 14.
Since patterns of cognitive dysfunction in mild Parkinson's disease associated with dementia (PDD) are similar to those in mild Alzheimer's disease (AD), it is difficult to accurately differentiate between these two types of dementia in their early phases using neuropsychological tests. The purpose of the current study was to investigate differences in cerebral perfusion patterns of patients with AD and PDD at the earliest stages using single photon emission computed tomography (SPECT).
We consecutively recruited 31 patients with mild PDD, 32 patients with mild probable AD and 33 age-matched healthy subjects. All subjects underwent (99m)Tc-hexamethylpropyleneamine oxime perfusion SPECT and completed general neuropsychological tests.
We found that both mild PDD and AD patients showed distinct hypoperfusion in frontal, parietal and temporal regions, compared with healthy subjects. More importantly, hypoperfusion in occipital and cerebellar regions was observed only in mild PDD.
The observation of a significant decrease in cerebral perfusion in occipital and cerebellar regions in patients with mild PDD is likely useful to differentiate between PDD and AD at the earliest stages.
由于轻度帕金森病伴发痴呆（PDD）的认知功能障碍模式与轻度阿尔茨海默病（AD）相似，因此在疾病早期很难通过神经心理学测试准确区分这两种类型的痴呆。本研究的目的是使用单光子发射计算机断层扫描（SPECT）研究AD和PDD患者在疾病最早期脑灌注模式的差异。
我们连续招募了31例轻度PDD患者、32例轻度可能的AD患者和33例年龄匹配的健康受试者。所有受试者均接受了（99m）锝-六甲基丙烯胺肟灌注SPECT检查，并完成了一般神经心理学测试。
我们发现，与健康受试者相比，轻度PDD和AD患者在额叶、顶叶和颞叶区域均表现出明显的灌注不足。更重要的是，仅在轻度PDD患者中观察到枕叶和小脑区域的灌注不足。
观察到轻度PDD患者枕叶和小脑区域脑灌注显著降低，这可能有助于在疾病最早期区分PDD和AD。
