Conti F, Weinberg R J
Istituto di Fisiologia Umana, Università di Ancona, I-60020 Ancona, Italy.
Trends Neurosci. 1999 Oct;22(10):451-8. doi: 10.1016/s0166-2236(99)01445-9.
Glutamatergic synapses vary, exhibiting EPSCs of widely different magnitudes and timecourses. The main contributors to this variability are: presynaptic factors, including release probability, quantal content and vesicle composition; factors that modulate the concentration and longevity of glutamate in the cleft, including diffusion and the actions of glutamate transporters; and postsynaptic factors, including the types and locations of ionotropic glutamate receptors, their numbers, and the nature and locations of associated intracellular signalling systems.
谷氨酸能突触具有多样性，表现出幅度和时程差异很大的兴奋性突触后电流（EPSCs）。造成这种变异性的主要因素有：突触前因素，包括释放概率、量子含量和囊泡组成；调节突触间隙中谷氨酸浓度和寿命的因素，包括扩散和谷氨酸转运体的作用；以及突触后因素，包括离子型谷氨酸受体的类型和位置、其数量以及相关细胞内信号系统的性质和位置。
