Fliegel L
Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
J Thromb Thrombolysis. 1999 Jul;8(1):9-14. doi: 10.1023/a:1008934312429.
The Na(+)/H(+) exchanger is a pH-regulatory protein present in the plasma membrane of cardiomyocytes and other cell types. In response to intracellular acidosis, the protein removes one intracellular proton in exchange for an extracellular sodium. The protein consists of a membrane transporting domain and a regulatory cytosolic domain. The regulatory cytosolic domain mediates the stimulation of the membrane domain. Hormonal stimulation of myocardial cells results in activation of the antiporter, possibly through protein kinases and other regulatory proteins. Several hormones and growth factors have been shown to stimulate the antiporter in the myocardium, including endothelin, thrombin, angiotensin II, and alpha(1)-adrenergic stimulation. The exact mechanisms involved in this stimulation are as yet unclear, and may be important in regulation of the Na(+)/H(+) exchanger during ischemia and reperfusion.
钠氢交换体是一种存在于心肌细胞和其他细胞类型质膜中的pH调节蛋白。响应细胞内酸中毒时，该蛋白会将一个细胞内质子移出，以交换一个细胞外钠离子。该蛋白由一个膜转运结构域和一个调节性胞质结构域组成。调节性胞质结构域介导对膜结构域的刺激。心肌细胞的激素刺激会导致该反向转运体的激活，可能是通过蛋白激酶和其他调节蛋白实现的。已表明几种激素和生长因子可刺激心肌中的反向转运体，包括内皮素、凝血酶、血管紧张素II和α1肾上腺素能刺激。这种刺激所涉及的确切机制尚不清楚，并且在缺血和再灌注期间对钠氢交换体的调节中可能很重要。
