基因组分析中缺失的一种古菌氨酰-tRNA合成酶。
An archaeal aminoacyl-tRNA synthetase missing from genomic analysis.
作者信息
Hamann C S, Sowers K R, Lipman R S, Hou Y M
机构信息
Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
出版信息
J Bacteriol. 1999 Sep;181(18):5880-4. doi: 10.1128/JB.181.18.5880-5884.1999.
Abstract
The complete genomic sequencing of Methanococcus jannaschii cannot identify the gene for the cysteine-specific member of aminoacyl-tRNA synthetases. However, we show here that enzyme activity is present in the cell lysate of M. jannaschii. The demonstration of this activity suggests a direct pathway for the synthesis of cysteinyl-tRNA(Cys) during protein synthesis.
摘要
詹氏甲烷球菌的全基因组测序无法鉴定出氨酰 - tRNA合成酶的半胱氨酸特异性成员的基因。然而，我们在此表明，詹氏甲烷球菌的细胞裂解物中存在该酶活性。这种活性的证明表明了在蛋白质合成过程中半胱氨酰 - tRNA（Cys）合成的直接途径。
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