Klenk H P, Clayton R A, Tomb J F, White O, Nelson K E, Ketchum K A, Dodson R J, Gwinn M, Hickey E K, Peterson J D, Richardson D L, Kerlavage A R, Graham D E, Kyrpides N C, Fleischmann R D, Quackenbush J, Lee N H, Sutton G G, Gill S, Kirkness E F, Dougherty B A, McKenney K, Adams M D, Loftus B, Peterson S, Reich C I, McNeil L K, Badger J H, Glodek A, Zhou L, Overbeek R, Gocayne J D, Weidman J F, McDonald L, Utterback T, Cotton M D, Spriggs T, Artiach P, Kaine B P, Sykes S M, Sadow P W, D'Andrea K P, Bowman C, Fujii C, Garland S A, Mason T M, Olsen G J, Fraser C M, Smith H O, Woese C R, Venter J C
Institute for Genomic Research, Rockville, Maryland 20850, USA.
Nature. 1997 Nov 27;390(6658):364-70. doi: 10.1038/37052.
Archaeoglobus fulgidus is the first sulphur-metabolizing organism to have its genome sequence determined. Its genome of 2,178,400 base pairs contains 2,436 open reading frames (ORFs). The information processing systems and the biosynthetic pathways for essential components (nucleotides, amino acids and cofactors) have extensive correlation with their counterparts in the archaeon Methanococcus jannaschii. The genomes of these two Archaea indicate dramatic differences in the way these organisms sense their environment, perform regulatory and transport functions, and gain energy. In contrast to M. jannaschii, A. fulgidus has fewer restriction-modification systems, and none of its genes appears to contain inteins. A quarter (651 ORFs) of the A. fulgidus genome encodes functionally uncharacterized yet conserved proteins, two-thirds of which are shared with M. jannaschii (428 ORFs). Another quarter of the genome encodes new proteins indicating substantial archaeal gene diversity.
嗜热栖热菌是首个基因组序列被测定的硫代谢生物。其2178400个碱基对的基因组包含2436个开放阅读框（ORF）。信息处理系统以及必需成分（核苷酸、氨基酸和辅因子）的生物合成途径与古菌詹氏甲烷球菌中的对应部分有广泛关联。这两种古菌的基因组表明，这些生物体感知环境、执行调节和运输功能以及获取能量的方式存在显著差异。与詹氏甲烷球菌不同，嗜热栖热菌的限制修饰系统较少，且其基因似乎均不包含内含肽。嗜热栖热菌基因组的四分之一（651个ORF）编码功能尚未明确但保守的蛋白质，其中三分之二与詹氏甲烷球菌共有（428个ORF）。基因组的另外四分之一编码新蛋白质，这表明古菌基因具有丰富的多样性。
