氨酰-tRNA合成：通向共同目标的不同途径。

Aminoacyl-tRNA synthesis: divergent routes to a common goal.

作者信息

Ibba M, Curnow A W, Söll D

机构信息

Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520-8114, USA.

出版信息

Trends Biochem Sci. 1997 Feb;22(2):39-42. doi: 10.1016/s0968-0004(96)20033-7.

DOI:10.1016/s0968-0004(96)20033-7

PMID:9048478

Abstract

Aminoacyl-tRNAs are key components in protein synthesis. They are formed directly by correct acylation of tRNA (by aminoacyl-tRNA synthetases) or indirectly by tRNA-dependent transformation of misacylated tRNAs. The accuracy of aminoacyl-tRNA synthesis is enhanced by a number of further protein-RNA or protein-protein interactions, some of which are restricted to Archaea, and might reflect adaptation mechanisms to diverse conditions.

摘要

氨酰-tRNA是蛋白质合成中的关键成分。它们直接通过tRNA的正确酰化作用（由氨酰-tRNA合成酶催化）形成，或者间接通过错配酰化tRNA的tRNA依赖性转化形成。多种进一步的蛋白质-RNA或蛋白质-蛋白质相互作用提高了氨酰-tRNA合成的准确性，其中一些相互作用仅限于古菌，可能反映了对不同条件的适应机制。