Previderé C, Stuppia L, Gatta V, Fattorini P, Palka G, Tyler-Smith C
CRC Chromosome Molecular Biology Group, Department of Biochemistry, University of Oxford, UK.
Eur J Hum Genet. 1999 Sep;7(6):733-6. doi: 10.1038/sj.ejhg.5200359.
Y-chromosomal DNA haplotypes were determined in 74 infertile and 216 control Italian males using eight biallelic markers. A significant difference in haplotype frequency was found, but could be explained by the geographical origins of the samples. The Y chromosome is thus a sensitive marker for population substructuring and may be useful for determining whether two population samples come from a single population, for example in association studies.
利用8个双等位基因标记，对74名意大利不育男性和216名对照男性进行了Y染色体DNA单倍型测定。发现单倍型频率存在显著差异，但这可以用样本的地理来源来解释。因此，Y染色体是群体亚结构的一个敏感标记，可能有助于确定两个群体样本是否来自同一群体，例如在关联研究中。
