Dupuy Berit Myhre, Stenersen Margurethe, Lu Tim T, Olaisen Bjørnar
Institute of Forensic Medicine, University of Oslo, Rikshospitalet, Oslo, Norway.
Forensic Sci Int. 2006 Dec 1;164(1):10-9. doi: 10.1016/j.forsciint.2005.11.009. Epub 2005 Dec 7.
Y-chromosomal variation at five biallelic markers (Tat, YAP, 12f2, SRY(10831) and 92R7) and nine multiallelic short tandem repeat (STR) loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385I/II and DYS388) in a Norwegian population sample are presented. The material consists of 1766 unrelated males of Norwegian origin. The geographical distribution of the population sample reflects fairly well the population distribution around the year 1942, which is the median birth year of the index persons. Seven hundred and twenty-one different Y-STR haplotypes but 726 different lineages (Y-STRs plus biallelic markers) were encountered. We observed six known (P*(xR1a), BR(xDE, J, N3, P), R1a, N3, DE, J), and one previously undescribed haplogroup (probably a subgroup within haplogroup P*(xR1a)). Four of the haplogroups (P*(xR1a), BR(xDE, J, N3, P), R1a and N3) represented about 98% of the population sample. The analysis of population pairwise differences indicates that the Norwegian Y-chromosome distribution most closely resembles those observed in Iceland, Germany, the Netherlands and Denmark. Within Norway, geographical substructuring was observed between regions and counties. The substructuring reflects to some extent the European Y-chromosome gradients, with higher frequency of P*(xR1a) in the south-west and of R1a in the east. Heterogeneity in major founder groups, geographical isolation, severe epidemics, historical trading links and population movements may have led to population stratification and have most probably contributed to the observed regional differences in distribution of haplotypes within two of the major haplogroups.
本文展示了挪威人群样本中五个双等位基因标记（Tat、YAP、12f2、SRY(10831)和92R7）以及九个多等位基因短串联重复序列（STR）位点（DYS19、DYS389I、DYS389II、DYS390、DYS391、DYS392、DYS393、DYS385I/II和DYS388）的Y染色体变异情况。材料包括1766名挪威裔无血缘关系男性。该人群样本的地理分布较好地反映了1942年左右的人口分布情况，1942年是索引人群的中位出生年份。共发现721种不同的Y-STR单倍型，但有726种不同的谱系（Y-STR加上双等位基因标记）。我们观察到六种已知的单倍群（P*(xR1a)、BR(xDE、J、N3、P)、R1a、N3、DE、J），以及一个先前未描述的单倍群（可能是P*(xR1a)单倍群内的一个亚群）。其中四个单倍群（P*(xR1a)、BR(xDE、J、N3、P)、R1a和N3）约占人群样本的98%。群体间差异分析表明，挪威Y染色体分布与冰岛、德国、荷兰和丹麦观察到的情况最为相似。在挪威境内，不同地区和郡县之间存在地理亚结构。这种亚结构在一定程度上反映了欧洲Y染色体梯度，西南部P*(xR1a)频率较高，东部R1a频率较高。主要奠基人群的异质性、地理隔离、严重疫情、历史贸易联系和人口迁移可能导致了人口分层，很可能是造成两个主要单倍群内观察到的单倍型分布区域差异的原因。
