Chowla A, Malhi-Chowla N, Chidambaram A, Surick B
Division of Surgery, Mayo Clinic Jacksonville, Florida 32224, USA.
Am Surg. 1999 Sep;65(9):881-3.
Primary B-cell lymphoma of the liver is an extremely rare tumor. The higher incidence of hepatocellular carcinoma in hepatitis C is well known, but the relationship with lymphoma is unclear. An increased incidence has been reported in patients with chronic hepatitis C. Hepatitis C virus is known to be a lymphotropic virus. Mixed cryoglobulinemia, which is a benign lymphoproliferative disorder, has a definite association with hepatitis C. It is postulated that the virus may also induce a malignant transformation. We describe an unusual presentation of a case of asymptomatic left hepatic mass in a patient with hepatitis C with a preoperative diagnosis of hepatocellular carcinoma. He underwent a left lateral segmentectomy, and the pathologic examination revealed non-Hodgkin's lymphoma. The clinical features, radiologic investigations, and pathologic findings are presented. A review of the literature discussing clinical features, postulated pathogenetic mechanisms, and management options is also presented.
肝脏原发性B细胞淋巴瘤是一种极其罕见的肿瘤。丙型肝炎患者中肝细胞癌的发病率较高是众所周知的，但与淋巴瘤的关系尚不清楚。据报道，慢性丙型肝炎患者的发病率有所增加。丙型肝炎病毒是一种嗜淋巴细胞病毒。混合性冷球蛋白血症是一种良性淋巴增殖性疾病，与丙型肝炎有明确关联。据推测，该病毒也可能诱导恶性转化。我们描述了一例丙型肝炎患者无症状左肝肿块的不寻常表现，术前诊断为肝细胞癌。他接受了左外侧叶切除术，病理检查显示为非霍奇金淋巴瘤。本文介绍了其临床特征、影像学检查和病理结果。还对讨论临床特征、假定的发病机制和治疗选择的文献进行了综述。
