Olsen J H, Mellemkjaer L, Gridley G, Brinton L, Johansen C, Kjaer S K
Research Department II, Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.
Am J Obstet Gynecol. 1999 Sep;181(3):630-4. doi: 10.1016/s0002-9378(99)70504-1.
It was our aim to evaluate the hypothesis that molar pregnancy is a marker of increased risk for cancer.
This was a nationwide cohort study of 1520 women, identified from the Danish National Register of Patients, in whom a molar pregnancy was diagnosed during the period 1977-1992 and of 1295 male partners of these women, traced in the Danish Central Population Register.
Linkage of the female roster with the Danish Cancer Registry through 1994 revealed 19 cases of gestational choriocarcinoma, whereas 0.04 was expected from the rates for the general population. Twenty cases of cancers of other types were observed with 24.9 expected (standardized incidence ratio, 0.8; 95% confidence interval, 0.5-1.2), but no specific type of cancer other than gestational choriocarcinoma occurred at a rate significantly different from that expected. Among the 1295 male partners notified in the Central Population Register, a total of 22 cancers were observed with 21.9 expected (standardized incidence ratio, 1.0; 95% confidence interval, 0.7-1.5).
Molar pregnancy is not associated with an increased risk for cancer other than gestational carcinoma.
我们旨在评估葡萄胎是癌症风险增加的标志物这一假说。
这是一项全国性队列研究，从丹麦国家患者登记册中识别出1520名女性，她们在1977年至1992年期间被诊断为葡萄胎，以及这些女性的1295名男性伴侣，通过丹麦中央人口登记册进行追踪。
通过1994年将女性名单与丹麦癌症登记册进行关联，发现19例妊娠滋养细胞肿瘤，而根据一般人群发病率预期为0.04例。观察到20例其他类型癌症，预期为24.9例（标准化发病率，0.8；95%置信区间，0.5 - 1.2），但除妊娠滋养细胞肿瘤外，没有其他特定类型癌症的发生率与预期有显著差异。在中央人口登记册中通知的1295名男性伴侣中，共观察到22例癌症，预期为21.9例（标准化发病率，1.0；95%置信区间，0.7 - 1.5）。
除妊娠滋养细胞肿瘤外，葡萄胎与癌症风险增加无关。
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