Loukovaara M, Pukkala E, Lehtovirta P, Leminen A
Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Finland.
Eur J Gynaecol Oncol. 2005;26(2):207-8.
Broad variations in the incidence of gestational trophoblastic diseases have been reported in different parts of the world. Recent time trends in the incidence of hydatidiform mole in Western countries have not been elucidated. We studied the epidemiology of hydatidiform mole in Finland over a period of 27 years.
Women reported to have hydatidiform mole from 1975-2001 were identified from the National Research and Development Center for Welfare and Health. Women with choriocarcinoma were identified from the Finnish Cancer Registry.
We identified 1659 cases of hydatidiform mole between 1975 and 2001. This gives an incidence of 73/10(6) women or 984/10(6) deliveries. The overall incidence remained fairly constant over the study period. The incidence was higher in women below 20 years and above 39 years than in women in the other age groups. Forty-nine percent of choriocarcinomas identified during the study period were associated with a preceding hydatidiform mole. The risk of choriocarcinoma after a hydatidiform mole was 2.2%.
The incidence of hydatidiform mole in Finland follows the same patterns as in other Western countries. The incidence has not changed considerably in recent decades.
世界各地报道的妊娠滋养细胞疾病发病率存在广泛差异。西方国家葡萄胎发病率的近期时间趋势尚未阐明。我们研究了芬兰27年间葡萄胎的流行病学情况。
从国家福利与健康研究与发展中心识别出1975年至2001年期间报告患有葡萄胎的女性。从芬兰癌症登记处识别出患有绒毛膜癌的女性。
我们在1975年至2001年间识别出1659例葡萄胎病例。这相当于每10⁶名女性中有73例发病，或每10⁶次分娩中有984例发病。在研究期间总体发病率保持相当稳定。20岁以下和39岁以上女性的发病率高于其他年龄组的女性。研究期间识别出的绒毛膜癌中有49%与先前的葡萄胎有关。葡萄胎后发生绒毛膜癌的风险为2.2%。
芬兰葡萄胎的发病率与其他西方国家的模式相同。近几十年来发病率没有显著变化。
