Wyler A R, Burchiel K J
Epilepsia. 1978 Dec;19(6):547-54. doi: 10.1111/j.1528-1157.1978.tb05035.x.
Five Macaca mulatta monkeys were operantly conditioned to control the firing patterns of single precentral pyramidal tract neurons. The accuracy with which the monkeys could control normal PTNs from within the focus was significantly poorer than PTNs from contralateral, homotopic cortex. In comparison to nonepileptic monkeys, there was no significant difference in the accuracy with which PTNs from cortex contralateral to interictal foci were controlled. By contrast, comparison of the time necessary to gain accurate control over individual PTNs from contralateral cortex showed the epileptic monkeys to be significantly encumbered when compared to nonepileptic monkeys. These data suggest that interictal foci produce "noise" in remote regions of brain that are involved in an operant task requiring a high degree of discrimination.
对五只恒河猴进行操作性条件训练，以控制单个中央前回锥体束神经元的放电模式。猴子从病灶内控制正常锥体束神经元的准确性明显低于对侧、同位皮层的锥体束神经元。与非癫痫猴子相比，发作间期病灶对侧皮层的锥体束神经元的控制准确性没有显著差异。相比之下，比较从对侧皮层获得对单个锥体束神经元的精确控制所需的时间，结果显示癫痫猴子与非癫痫猴子相比明显受到阻碍。这些数据表明，发作间期病灶在参与需要高度辨别力的操作性任务的脑区远程区域产生“噪声”。
