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[针对危险传染病的气溶胶疫苗接种]

[Aerosol vaccination against dangerous infectious diseases].

作者信息

Stepanov A V, Marinin L I, Vorob'ev A A

出版信息

Vestn Ross Akad Med Nauk. 1999(8):47-54.

PMID:10487124
Abstract

The paper summarizes the results of development of the aerosol method, one of the mass ways of human vaccination. Analysis of materials suggests that Russia has designed highly effective live plague, tularemia, and anthrax vaccines that can be used to immunize in different ways: by epicutaneous and subcutaneous, and inhalation routes. The advantages and disadvantages of aerosol vaccination are shown. The correct use of this method provides a substantial effect when the epidemic situation is complicated and when there is a need for vaccination of large cohorts at the earliest possible time.

摘要

本文总结了气溶胶法(大规模人类疫苗接种方式之一)的研发成果。对相关资料的分析表明,俄罗斯已研制出高效的鼠疫、兔热病和炭疽活菌疫苗,这些疫苗可通过不同方式进行免疫接种:皮上、皮下和吸入途径。文中展示了气溶胶接种的优缺点。在疫情复杂以及需要尽早对大批人群进行接种时,正确使用该方法能产生显著效果。

相似文献

1
[Aerosol vaccination against dangerous infectious diseases].[针对危险传染病的气溶胶疫苗接种]
Vestn Ross Akad Med Nauk. 1999(8):47-54.
2
[Current status of vaccine treatment of zoonotic infections].[人畜共患感染的疫苗治疗现状]
Voen Med Zh. 1980 Sep(9):47-50.
3
Single vector platform vaccine protects against lethal respiratory challenge with Tier 1 select agents of anthrax, plague, and tularemia.单载体平台疫苗可预防炭疽、鼠疫和兔热病 1 级选择剂的致死性呼吸道挑战。
Sci Rep. 2018 May 3;8(1):7009. doi: 10.1038/s41598-018-24581-y.
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[Plague, tularemia and anthrax immunization with associated di- and trivaccines using a jet injector. I].[使用喷射注射器进行鼠疫、土拉菌病和炭疽联合二价及三价疫苗免疫。I]
Zh Mikrobiol Epidemiol Immunobiol. 1974;00(5):59-64.
5
[Cross immunity to plague and tularemia].[鼠疫与土拉菌病的交叉免疫]
Zh Mikrobiol Epidemiol Immunobiol. 1980(2):49-52.
6
[Jet immunization with polyvalent vaccine against plague, tularemia, and anthrax].用抗鼠疫、土拉菌病和炭疽的多价疫苗进行喷射免疫
Zh Mikrobiol Epidemiol Immunobiol. 1980 Jun(6):109-10.
7
[The time course of changes in cell immunological parameters during administration of live dry plague vaccine].[冻干鼠疫活菌苗接种期间细胞免疫学参数的动态变化]
Klin Lab Diagn. 2009 Aug(8):24-7.
8
[Cytochemical changes in the peripheral blood leukocytes of guinea pigs inoculated against plague, tularemia and anthrax].[接种鼠疫、土拉菌病和炭疽疫苗的豚鼠外周血白细胞的细胞化学变化]
Zh Mikrobiol Epidemiol Immunobiol. 1982 Jul(7):73-6.
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[The effect of aerosolization on the changes in major biological properties of the vaccine strain of Francisella tularensis].[雾化对土拉热弗朗西斯菌疫苗株主要生物学特性变化的影响]
Zh Mikrobiol Epidemiol Immunobiol. 1983 Jun(6):26-9.
10
Correlates of protection following vaccination of mice with gene deletion mutants of Francisella tularensis subspecies tularensis strain, SCHU S4 that elicit varying degrees of immunity to systemic and respiratory challenge with wild-type bacteria.经基因缺失突变的土拉弗朗西斯菌亚种土拉弗朗西斯菌 SCHU S4 菌株免疫接种的小鼠,对野生型细菌引起的全身和呼吸道挑战的保护相关性,其免疫程度存在差异。
Mol Immunol. 2013 May;54(1):58-67. doi: 10.1016/j.molimm.2012.10.043. Epub 2012 Nov 28.

引用本文的文献

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Protection Elicited by Attenuated Live Vaccine Strains against Lethal Infection with Virulent .减毒活疫苗株诱导的针对强毒株致死性感染的保护作用
Vaccines (Basel). 2021 Feb 16;9(2):161. doi: 10.3390/vaccines9020161.
2
Russian vaccines against especially dangerous bacterial pathogens.针对特别危险的细菌病原体的俄罗斯疫苗。
Emerg Microbes Infect. 2014 Dec;3(12):e86. doi: 10.1038/emi.2014.82. Epub 2014 Dec 17.