Safronova V M, Loktev N A, Basilova G I, Pilipenko V G
Zh Mikrobiol Epidemiol Immunobiol. 1982 Jul(7):73-6.
The immunization of guinea pigs with trivaccine and monovaccines against plaque, tularemia and anthrax induces a decrease in the activity of acidic phosphatase in lymphocytes, as well as a decrease in the number of lymphocytes containing this enzyme. A decrease in the activity of alkaline phosphatase and peroxidase had been found to occur in neutrophil leukocytes. Besides, neutrophil leukocytes have shown an increase in the activity of acidic phosphatase and nonspecific esterases. The study based on the evaluation of the activity of the above-mentioned enzymes in lymphocytes and neutrophils has not revealed the predominant influence exercised by any of the antigens, different in their nature and used separately or in the form of a combined preparation, on immunogenesis.
用抗鼠疫、兔热病和炭疽的三联疫苗及单价疫苗对豚鼠进行免疫接种，会导致淋巴细胞中酸性磷酸酶的活性降低，以及含有该酶的淋巴细胞数量减少。已发现中性粒细胞中碱性磷酸酶和过氧化物酶的活性降低。此外，中性粒细胞中酸性磷酸酶和非特异性酯酶的活性有所增加。基于对淋巴细胞和中性粒细胞中上述酶活性的评估所开展的研究，未揭示任何一种性质不同、单独使用或以联合制剂形式使用的抗原对免疫发生的主要影响。
