Liu Y, Heintzen C, Loros J, Dunlap J C
Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.
Cell Mol Life Sci. 1999 Aug 15;55(10):1195-205. doi: 10.1007/s000180050366.
A recent explosion in the identification of new clock components in cyanobacteria, fungi, insects, mammals as well as potential candidates in plants has uncovered common themes among the structure, function and regulation of these components. Positive and negative interactions that are organized in negative feedback loops have been found crucial for clock function. Both transcriptional and posttranscriptional mechanisms appear to be important for circadian rhythm generation in all of these organisms.
最近，在蓝细菌、真菌、昆虫、哺乳动物中发现了大量新的生物钟组件，同时也发现了植物中的潜在候选组件，这些发现揭示了这些组件在结构、功能和调控方面的共同主题。以负反馈回路组织的正向和负向相互作用对于生物钟功能至关重要。转录和转录后机制似乎对所有这些生物体的昼夜节律产生都很重要。
