Krasowski M D, Harrison N L
Committee on Neurobiology, University of Chicago, Whitman Laboratory, Illinois 60637, USA.
Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. doi: 10.1007/s000180050371.
The molecular mechanisms of general anaesthetics have remained largely obscure since their introduction into clinical practice just over 150 years ago. This review describes the actions of general anaesthetics on mammalian neurotransmitter-gated ion channels. As a result of research during the last several decades, ligand-gated ion channels have emerged as promising molecular targets for the central nervous system effects of general anaesthetics. The last 10 years have witnessed an explosion of studies of anaesthetic modulation of recombinant ligand-gated ion channels, including recent studies which utilize chimeric and mutated receptors to identify regions of ligand-gated ion channels important for the actions of general anaesthetics. Exciting future directions include structural biology and gene-targeting approaches to further the understanding of general anaesthetic molecular mechanisms.
自150多年前全身麻醉药被引入临床实践以来，其分子机制在很大程度上一直不清楚。这篇综述描述了全身麻醉药对哺乳动物神经递质门控离子通道的作用。经过过去几十年的研究，配体门控离子通道已成为全身麻醉药中枢神经系统效应的有前景的分子靶点。过去10年见证了对重组配体门控离子通道麻醉调节的研究激增，包括最近利用嵌合和突变受体来确定配体门控离子通道中对全身麻醉药作用重要区域的研究。令人兴奋的未来方向包括结构生物学和基因靶向方法，以进一步了解全身麻醉药的分子机制。
