促肾上腺皮质激素诱导的小母牛卵巢卵泡囊肿对外源性雌二醇缺乏促黄体生成素反应。

Lack of LH response to exogenous estradiol in heifers with ACTH-induced ovarian follicular cysts.

作者信息

Ribadu A Y, Nakada K, Tanaka Y, Moriyoshi M, Zhang W C, Nakao T

机构信息

Department of Veterinary Obstetrics & Gynecology, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.

出版信息

J Vet Med Sci. 1999 Aug;61(8):979-81. doi: 10.1292/jvms.61.979.

DOI:10.1292/jvms.61.979

PMID:10487246

Abstract

The aim of the present study was to examine the LH response to exogenous estradiol in 4 heifers with ACTH-induced ovarian follicular cysts. During the control experiment, administration of estradiol 24 hr after PGF2alpha in luteal phase heifers resulted in a LH response in all 4 heifers. The LH response was obtained between 16-20 hr after estradiol administration. The peak LH concentration (Mean +/- SEM; 5.1 +/- 0.8 ng/ml) during the control study was significantly different (P<0.05) from the concentration after cyst formation. None of the 4 heifers responded to estradiol after ovarian cyst formation. This result suggests that heifers with ACTH-induced ovarian follicular cysts may have a defective hypothalamio-pituitary response to exogenous estradiol similar to cows with spontaneous ovarian cysts.

摘要

本研究的目的是检测4头患有促肾上腺皮质激素诱导性卵巢卵泡囊肿的小母牛对外源性雌二醇的促黄体生成素（LH）反应。在对照实验中，黄体期小母牛在注射前列腺素F2α（PGF2α）24小时后给予雌二醇，所有4头小母牛均出现LH反应。LH反应在给予雌二醇后16 - 20小时出现。对照研究期间促黄体生成素的峰值浓度（平均值±标准误；5.1±0.8纳克/毫升）与囊肿形成后的浓度有显著差异（P<0.05）。4头小母牛在卵巢囊肿形成后均未对雌二醇产生反应。这一结果表明，患有促肾上腺皮质激素诱导性卵巢卵泡囊肿的小母牛可能存在类似于患有自发性卵巢囊肿的母牛对外源性雌二醇的下丘脑 - 垂体反应缺陷。