McCluskey L, Feinberg D, Cantor C, Bird S
Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Muscle Nerve. 1999 Oct;22(10):1361-6. doi: 10.1002/(sici)1097-4598(199910)22:10<1361::aid-mus4>3.0.co;2-1.
The predominant electrophysiologic feature of vasculitic mononeuropathy multiplex is axonal loss. Electrophysiologic findings interpreted as conduction block have, however, also been reported to occur in neuropathy secondary to necrotizing vasculitis. We report 3 patients with mononeuropathy multiplex and biopsy proven vasculitis in whom eight nerves met criteria for conduction block. In each circumstance, serial study demonstrated conversion of the electrophysiologic findings to those most consistent with severe axonal loss. "Conduction block" in vasculitic mononeuropathy multiplex is secondary to focal axonal conduction failure presumably related to infarctive axonal injury. The term conduction block should be used with caution in this disorder and only if serial studies demonstrate findings consistent with this electrophysiologic diagnosis.
血管炎性多神经病的主要电生理特征是轴突丧失。然而，也有报道称，在继发于坏死性血管炎的神经病变中，电生理检查结果可解释为传导阻滞。我们报告了3例多神经病且活检证实为血管炎的患者，其中8条神经符合传导阻滞标准。在每种情况下，系列研究均显示电生理检查结果转变为与严重轴突丧失最为一致的结果。血管炎性多神经病中的“传导阻滞”继发于局灶性轴突传导衰竭，可能与缺血性轴突损伤有关。在这种疾病中，应谨慎使用传导阻滞这一术语，且仅当系列研究显示的结果符合这一电生理诊断时方可使用。
