Kang Min K, Gupta Rajesh K, Srinivasan Jayashri
Department of Neurology, Lahey Hospital and Medical Center, Burlington, MA.
Department of Neurology, Tufts Medical Center, Boston, MA.
J Clin Neuromuscul Dis. 2018 Mar;19(3):138-141. doi: 10.1097/CND.0000000000000197.
We describe 2 patients presenting with multiplex mononeuritis, associated with skin manifestation, secondary to minocycline-induced vasculitis. One of the cases is associated neither with lupus nor polyarteritis nodosa. An extensive laboratory workup ruled out any possible underlying immunologic disorder. Electrodiagnostic studies were conducted to show axonal neuropathy in patchy and multifocal distribution consistent with multiplex mononeuritis. This diagnosis was confirmed with nerve biopsy. Withdrawing from the offending medication, minocycline, improved the patients' clinical condition and the quantitative serological measures.
我们描述了2例患者，他们表现为多发型单神经炎，并伴有皮肤表现，继发于米诺环素诱导的血管炎。其中1例既与狼疮无关，也与结节性多动脉炎无关。广泛的实验室检查排除了任何可能的潜在免疫性疾病。进行了电诊断研究，结果显示为斑片状和多灶性分布的轴索性神经病，与多发型单神经炎一致。神经活检证实了这一诊断。停用致病药物米诺环素后，患者的临床状况和定量血清学指标有所改善。
