Dunn J F, Zaim-Wadghiri Y
Biomedical NMR Research Center, Department of Diagnostic Radiology, Dartmouth Hitchcock Medical Center, 7786 Vail, Hanover, New Hampshire 03755, USA.
Muscle Nerve. 1999 Oct;22(10):1367-71. doi: 10.1002/(sici)1097-4598(199910)22:10<1367::aid-mus5>3.0.co;2-h.
The mdx mouse has a genetically homologous disease to Duchenne muscular dystrophy in humans. The disease progression, however, is not accompanied by the same level of fatty infiltration and muscle degeneration as occurs in humans. Thus, the presence of histological/pathological changes in living mdx mice has been difficult to monitor. We quantified proton density and the T2 relaxation time of protons with a resolution of 195 x 195 x 1000 microm using multiecho magnetic resonance (MR) imaging at 7 Tesla. These relaxation data were correlated with water content in both muscle and brain of mdx and controls. No differences were observed in brain. The mdx muscles had increased water content and proton density and decreased T2 relative to controls. These data indicate that there are intrinsic changes in T2 (opposite to that which would be induced by fatty infiltration) and suggest that T2 imaging could be used to monitor progression and treatment in this animal model.
mdx小鼠患有一种与人类杜氏肌营养不良症基因同源的疾病。然而，其疾病进展过程中并未伴随人类那样程度的脂肪浸润和肌肉退化。因此，很难监测活体mdx小鼠组织学/病理学变化的存在情况。我们使用7特斯拉的多回波磁共振（MR）成像，以195×195×1000微米的分辨率对质子密度和质子的T2弛豫时间进行了量化。这些弛豫数据与mdx小鼠和对照小鼠肌肉及大脑中的含水量相关。在大脑中未观察到差异。与对照相比，mdx小鼠的肌肉含水量和质子密度增加，T2降低。这些数据表明T2存在内在变化（与脂肪浸润所诱导的变化相反），并表明T2成像可用于监测该动物模型中的疾病进展和治疗情况。
