Zaoutis T, Schneider B, Steele Moore L, Klein J D
Division of Pediatric Infectious Diseases, Alfred I. duPont Hospital for Children, Wilmington, Delaware 19899, USA.
J Clin Microbiol. 1999 Oct;37(10):3380-3. doi: 10.1128/JCM.37.10.3380-3383.1999.
A retrospective review of medical records for 32 patients with invasive group C streptococcus (GCS) or group G streptococcus (GGS) infections was performed. MICs and minimum bactericidal concentrations (MBCs) of penicillin, erythromycin, and vancomycin for all isolates were obtained. Tolerance of vancomycin, defined as an MBC 32 or more times higher than the MIC, was exhibited by 18 GGS isolates (54%). The identification of tolerance in clinical isolates of GGS and GCS may have clinical implications in treating these seriously ill patients.
对32例侵袭性C组链球菌(GCS)或G组链球菌(GGS)感染患者的病历进行了回顾性研究。获得了所有分离株对青霉素、红霉素和万古霉素的最低抑菌浓度(MIC)和最低杀菌浓度(MBC)。18株GGS分离株(54%)表现出万古霉素耐受性,定义为MBC比MIC高32倍或更多倍。在GGS和GCS临床分离株中鉴定出耐受性可能对治疗这些重症患者具有临床意义。