Jacobs J A, Pietersen H G, Stobberingh E E, Soeters P B
Department of Medical Microbiology, University Hospital of Maastricht, The Netherlands.
Clin Infect Dis. 1994 Oct;19(4):704-13. doi: 10.1093/clinids/19.4.704.
During a 3-year study period, 19 patients at the University Hospital of Maastricht developed bloodstream infections with species of the "Streptococcus milleri" group, for an incidence of 0.33 per 1,000 admissions. The patients' median age was 48 years; the male-to-female ratio was 2.8. Eleven patients (57.9%) had underlying diseases, among which malignancy was predominant. Local trauma to the mucosal barrier was an important risk factor. An associated site of infection was found most frequently in the abdominal and thoracic cavities (nine and five cases, respectively). Bacteremia was polymicrobial in four of 19 episodes. The 20 infecting S. milleri strains were identified to the species level; Streptococcus anginosus was the most prevalent (16 strains). Eight strains carried Lancefield group C. The isolates were sensitive to most antibiotics. Abscess formation was documented in nine cases (47.3%); repeated drainage procedures were required in half of these episodes. Mortality was high (five of 19 patients, or 26.3%).
在一项为期3年的研究期间，马斯特里赫特大学医院有19名患者发生了“米勒链球菌”组细菌引起的血流感染，每1000例入院患者中的发病率为0.33。患者的中位年龄为48岁；男女比例为2.8。11名患者（57.9%）有基础疾病，其中以恶性肿瘤为主。黏膜屏障的局部创伤是一个重要的危险因素。感染相关部位最常见于腹腔和胸腔（分别为9例和5例）。19次菌血症发作中有4次为多微生物感染。对20株感染的米勒链球菌菌株进行了种水平鉴定；咽峡炎链球菌最为常见（16株）。8株携带兰斯菲尔德C组。分离株对大多数抗生素敏感。9例（47.3%）有脓肿形成记录；其中一半病例需要反复进行引流操作。死亡率很高（19名患者中有5名，即26.3%）。
