Lachmann B, Vogel J, Bergmann K C, Winsel K, Müller E, Petro W, Wuthe H, Eckert H
Z Erkr Atmungsorgane. 1976 Mar;144(3):207-13.
After injection of an anti-lung -serum a respiratory distress syndrome could be produced in spontaneously-breathing guinea pigs. Reduced compliance, increased resistance and work of breathing was found. Morphological investigations showed intraalveolar and interstitial bleedings and a lung edema. Biochemically a decreased total phospholipid content could be found. Surface tension characteristics, examined with the Langmuir balance, were deteriorated. A complete restitution of surface tension parameters and total phospholipid content was obtained by administration of bromhexin metabolit Na 872.
给自发呼吸的豚鼠注射抗肺血清后，可诱发呼吸窘迫综合征。发现顺应性降低、呼吸阻力和呼吸功增加。形态学研究显示肺泡内和间质出血以及肺水肿。生化分析发现总磷脂含量降低。用朗缪尔天平检测的表面张力特性变差。通过给予溴己新代谢物Na 872，表面张力参数和总磷脂含量完全恢复。
