Wicks T C
Department of Anesthesia, Catawba Memorial Hospital, Hickory, NC, USA.
AANA J. 1999 Apr;67(2):171-9.
Magnesium is the second most abundant intracellular cation in the human body and serves as an obligate cofactor in approximately 300 essential enzymatic cellular reactions. Magnesium is crucial for the generation and use of adenosine triphosphate and is required for oxidative phosphorylation. A wide variety of internal and external stresses have been found to increase a person's requirement for dietary magnesium. Magnesium deficiency may develop during a variety of pathological states, or it may have an iatrogenic basis. Magnesium deficiency complicates the management of hypertension and cardiac arrhythmias, affects the clinical behavior of neuromuscular blocking drugs, and may impair immune function.
镁是人体中含量第二丰富的细胞内阳离子，在大约300种基本的细胞酶促反应中作为必需的辅助因子。镁对于三磷酸腺苷的生成和利用至关重要，是氧化磷酸化所必需的。已发现多种内外部应激会增加人体对膳食镁的需求。镁缺乏可能在多种病理状态下发生，也可能有医源性原因。镁缺乏会使高血压和心律失常的管理复杂化，影响神经肌肉阻滞药物的临床作用，还可能损害免疫功能。
