镁代谢
Magnesium metabolism.
作者信息
Reinhart R A
机构信息
Cardiology Department, Marshfield Clinic, WI 54449.
出版信息
Wis Med J. 1990 Oct;89(10):579-83.
Magnesium is the second most abundant intracellular cation in the human body and is necessary as a cofactor in more than 300 enzymatic reactions. The generation and use of adenosine triphosphate is dependent on the presence of magnesium. The assessment of the magnesium status of a patient is problematic because there are no easily performed tests that reliably predict the intracellular concentration. There are recognized molecular and cellular actions of magnesium that explain clinically recognizable problems when a magnesium deficiency or excess is present. Guidelines for therapy of magnesium deficiency are given. Future directions in research are given.
镁是人体中含量第二丰富的细胞内阳离子，是300多种酶促反应中必需的辅助因子。三磷酸腺苷的生成和利用依赖于镁的存在。评估患者的镁状态存在问题，因为没有易于执行的测试能够可靠地预测细胞内浓度。镁具有公认的分子和细胞作用，这解释了镁缺乏或过量时临床上可识别的问题。本文给出了镁缺乏症的治疗指南，并指明了未来的研究方向。
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