Rudge M V, Gomes C M, Calderon I de M, Ramos M D, Abbade J F, de Oliveira M G, da Silva M G
Discipline of Obstetrics, Faculdade de Medicina de Botucatu, UNESP, Brazil.
Sao Paulo Med J. 1999 Mar 4;117(2):49-56. doi: 10.1590/s1516-31801999000200002.
Intrauterine growth retard (IUGR) continues to be a significant perinatology problem at the end of this century. The nature of the etiologic agent, the time when the attack occurred during pregnancy and its duration affect the type of IUGR.
To study the evolution of fetal pancreas and placenta between the 18th and 21st day of pregnancy in rats submitted to maternal protein-calorie restriction.
Randomized controlled trial on laboratory animal.
Forty-one normoglycemic pregnant Wistar rats.
Rats were divided into six experimental groups according to their access to food and date of cesarean section (18th or 21st day): control with free access to food; diet restricted to 25% introduced on 1st day of pregnancy; and diet restricted to 25% after the 3rd day of pregnancy.
Newborn weight, placenta weight, histopathological study (morphological histochemistry).
Maternal protein-calorie malnutrition caused intrauterine growth retard (IUGR) after the 18th day of pregnancy. Dietary restriction did not interfere with the morphology of the fetal pancreas and the immunohistochemical study of the placenta showed that glycogen stores were decreased between the 18th and 21st day in the control group and in a diet restricted to 25% from the first day of pregnancy. Dietary restriction after the 3rd day of pregnancy led to low placental glycogen concentrations on the 18th day and disappearance on the 21st day.
The pathophysiology of IUGR due to maternal protein-calorie restriction in rats is related to lower placental weight and low placental glycogen stores.
宫内生长迟缓（IUGR）在本世纪末仍然是围产医学中的一个重大问题。病因的性质、孕期发作的时间及其持续时间会影响IUGR的类型。
研究孕期蛋白质 - 热量限制的大鼠在妊娠第18天至21天期间胎儿胰腺和胎盘的发育情况。
对实验动物进行的随机对照试验。
41只血糖正常的怀孕Wistar大鼠。
根据大鼠获取食物的情况和剖宫产日期（第18天或第21天）将其分为六个实验组：自由获取食物的对照组；妊娠第1天开始饮食限制为25%；妊娠第3天后饮食限制为25%。
新生鼠体重、胎盘重量、组织病理学研究（形态组织化学）。
母体蛋白质 - 热量营养不良在妊娠第18天后导致宫内生长迟缓（IUGR）。饮食限制并未干扰胎儿胰腺的形态，胎盘的免疫组织化学研究表明，对照组以及妊娠第1天开始饮食限制为25%的组中，糖原储备在第18天至21天之间减少。妊娠第3天后进行饮食限制导致第18天胎盘糖原浓度降低，第21天消失。
大鼠因母体蛋白质 - 热量限制导致的IUGR的病理生理学与胎盘重量降低和胎盘糖原储备减少有关。
