Wu E B, Lumb P, Chambers J B, Crook M A
Cardiothoracic Centre, Guy's and St Thomas' Hospital, London, UK.
Atherosclerosis. 1999 Aug;145(2):261-6. doi: 10.1016/s0021-9150(99)00074-x.
Serum or plasma sialic acid and C-reactive protein have recently been shown to be cardiovascular risk factors. Our aim was to determine whether plasma sialic acid or C-reactive protein concentration correlate with atheromatous load on coronary angiography. Plasma sialic acid concentration and plasma C-reactive protein concentration were determined in 128 consecutive patients attending day case coronary angiography. Patients were excluded for previous coronary angioplasty, coronary artery bypass grafting, recent myocardial infarction, acute or chronic inflammatory disease and proximal occlusions precluding analysis of distal coronary anatomy. Total cholesterol, triglyceride, HDL cholesterol and glucose concentrations were assayed on fasting samples of venous blood. Angiograms were graded according to a semisubjective scoring system. There was no significant correlation between plasma sialic acid (r = 0.19, P = 0.07), or C-reactive protein concentration (r = 0.17, P = 0.13) and atheromatous load. There was no significant correlation between sialic acid (P = 0.13), or C-reactive protein concentration (P = 0.32) and the number of diseased coronary vessels. The difference in plasma sialic acid concentration between those with normal coronary angiograms and those with coronary artery disease did not reach significance (P = 0.08). Plasma sialic acid concentration correlated with C-reactive protein (r = 0.58, P = 0.0001), serum triglyceride (r = 0.32, P = 0.002), and blood cholesterol concentration (r = 0.22, P = 0.04). Plasma sialic acid concentration does not correlate with atheromatous load on coronary angiography in patients with stable angina.
血清或血浆唾液酸以及C反应蛋白最近已被证明是心血管危险因素。我们的目的是确定血浆唾液酸或C反应蛋白浓度是否与冠状动脉造影显示的动脉粥样硬化负荷相关。对128例接受日间冠状动脉造影的连续患者测定了血浆唾液酸浓度和血浆C反应蛋白浓度。排除曾接受冠状动脉成形术、冠状动脉旁路移植术、近期心肌梗死、急性或慢性炎症性疾病以及近端闭塞无法分析远端冠状动脉解剖结构的患者。对空腹静脉血样本检测总胆固醇、甘油三酯、高密度脂蛋白胆固醇和葡萄糖浓度。血管造影根据半主观评分系统进行分级。血浆唾液酸（r = 0.19，P = 0.07）或C反应蛋白浓度（r = 0.17，P = 0.13）与动脉粥样硬化负荷之间无显著相关性。唾液酸（P = 0.13）或C反应蛋白浓度（P = 0.32）与病变冠状动脉血管数量之间无显著相关性。冠状动脉造影正常者与冠状动脉疾病患者之间血浆唾液酸浓度差异无统计学意义（P = 0.08）。血浆唾液酸浓度与C反应蛋白（r = 0.58，P = 0.0001）、血清甘油三酯（r = 0.32，P = 0.002）和血胆固醇浓度（r = 0.22，P = 0.04）相关。稳定型心绞痛患者的血浆唾液酸浓度与冠状动脉造影显示的动脉粥样硬化负荷无关。
