Gokmen Selma Suer, Kilicli Gulseven, Ozcelik Fatih, Ture Mevlut, Gulen Sendogan
Department of Biochemistry, Trakya University School of Medicine, Edirne, Turkey.
J Lab Clin Med. 2002 Aug;140(2):110-8. doi: 10.1067/mlc.2002.126344.
Serum total sialic acid has recently been shown to be a cardiovascular risk factor. Increased levels of this substance are associated with higher cardiovascular mortality and with cerebrovascular disease. It has also been shown that serum concentrations of total and lipid-associated sialic acid are significantly increased in hypertriglyceridemia. On the other hand, several circulating lipoproteins have been suggested to be related to the severity of coronary atherosclerosis, but contradictory results have been reported in the possible relationship between the concentrations of sialic acid and the severity of coronary lesions in patients with coronary heart disease. The purpose of this study was to investigate the possible relationship between serum total sialic acid concentration, recently shown to be a cardiovascular risk factor, and serum lipid-bound sialic acid concentration and the severity of coronary lesions. The study comprised 90 subjects, divided into three subgroups according to angiography results: 30 patients with no vessel disease, 30 patients with single-vessel disease, and 30 patients with double/triple-vessel disease. Serum total sialic acid determination was carried out with the thiobarbituric acid method of Warren; lipid-associated sialic acid was assayed with the method of Katopodis. Mean serum total sialic acid levels in patients with single-vessel disease (P <.05) and patients with double/triple-vessel disease (P <.001) were found to be significantly increased compared with that in patients with no vessel disease, whereas mean serum lipid-bound sialic acid levels were found to be significantly different between patients with double- or triple-vessel disease and patients with no vessel disease (P <.001). We also noted a significant difference between the levels of serum total sialic acid (P <.001) and lipid-bound sialic acid (P <.001) in patients with single-vessel disease and patients with double/triple-vessel disease. We found a significant correlation only between serum lipid-bound sialic acid and coronary angiographic score in patients with double/triple-vessel disease (r = 0.425, P <.05). Although the concentration of serum total sialic acid is increased proportionally with the number of diseased coronary arteries, only the concentration of serum lipid-bound sialic acid is related to the severity of coronary atherosclerosis, especially in patients with double/triple-vessel disease.
血清总唾液酸最近被证明是一种心血管危险因素。这种物质水平的升高与更高的心血管死亡率以及脑血管疾病相关。研究还表明，高甘油三酯血症患者血清中总唾液酸和脂质相关唾液酸的浓度显著升高。另一方面，有研究提示几种循环脂蛋白与冠状动脉粥样硬化的严重程度有关，但关于冠心病患者唾液酸浓度与冠状动脉病变严重程度之间的可能关系，报道结果相互矛盾。本研究的目的是探讨最近被证明是心血管危险因素的血清总唾液酸浓度、血清脂质结合唾液酸浓度与冠状动脉病变严重程度之间的可能关系。该研究包括90名受试者，根据血管造影结果分为三个亚组：30名无血管疾病患者、30名单支血管疾病患者和30名双支/三支血管疾病患者。血清总唾液酸的测定采用沃伦的硫代巴比妥酸法；脂质相关唾液酸采用卡托波迪斯法测定。发现单支血管疾病患者（P <.05）和双支/三支血管疾病患者（P <.001）的血清总唾液酸平均水平与无血管疾病患者相比显著升高，而双支或三支血管疾病患者与无血管疾病患者之间的血清脂质结合唾液酸平均水平存在显著差异（P <.001）。我们还注意到单支血管疾病患者与双支/三支血管疾病患者的血清总唾液酸水平（P <.001）和脂质结合唾液酸水平（P <.001）存在显著差异。我们仅在双支/三支血管疾病患者中发现血清脂质结合唾液酸与冠状动脉造影评分之间存在显著相关性（r = 0.425，P <.05）。虽然血清总唾液酸浓度与病变冠状动脉数量成比例增加，但只有血清脂质结合唾液酸浓度与冠状动脉粥样硬化的严重程度相关，尤其是在双支/三支血管疾病患者中。
