Oren I, Brook J G, Gershoni-Baruch R, Kepten I, Tamir A, Linn S, Wolfovitz E
Rambam Medical Center, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
Atherosclerosis. 1999 Aug;145(2):267-71. doi: 10.1016/s0021-9150(99)00075-1.
Coronary artery disease is a polygenic disease whose phenotypic manifestation depends on the interaction of the genetic background with a number of environmental factors. Recently, the gene coding for the angiotensin-converting enzyme (ACE) has been characterized and a deletion/insertion (D/I) polymorphism was defined. The prevalence of the three genotypes and their association with coronary artery disease (CAD) differ in different population groups. Mostly, the D allele was found as a significant risk factor for CAD, independently from other risk factors. In the present study, we determined the distribution of ACE alleles (D or I) in a cohort of healthy Israeli men and examined the correlation of the different genotypes with various CAD risk factors. We found LDL cholesterol levels to be highest in the DD genotype group, intermediate in the DI genotype group and lowest in the II genotype group. We also found higher blood pressure levels in subjects bearing the D allele compared to II homozygous subjects. In conclusion, it appears that the genetic influence of the D/I polymorphism on CAD manifests primarily through traditional risk factors.
冠状动脉疾病是一种多基因疾病，其表型表现取决于遗传背景与多种环境因素的相互作用。最近，已对编码血管紧张素转换酶（ACE）的基因进行了表征，并定义了缺失/插入（D/I）多态性。三种基因型的患病率及其与冠状动脉疾病（CAD）的关联在不同人群中有所不同。大多数情况下，发现D等位基因是CAD的一个重要危险因素，独立于其他危险因素。在本研究中，我们确定了一组健康以色列男性中ACE等位基因（D或I）的分布，并检查了不同基因型与各种CAD危险因素的相关性。我们发现DD基因型组的低密度脂蛋白胆固醇水平最高，DI基因型组居中，II基因型组最低。我们还发现携带D等位基因的受试者的血压水平高于II纯合子受试者。总之，似乎D/I多态性对CAD的遗传影响主要通过传统危险因素表现出来。
