Delanghe J, Langlois M, Duprez D, De Buyzere M, Clement D
Department of Clinical Chemistry, University Hospital Gent, Belgium.
Atherosclerosis. 1999 Aug;145(2):287-92. doi: 10.1016/s0021-9150(99)00079-9.
Haptoglobin (Hp) 2-2 phenotype is a genetic risk factor in coronary atherosclerosis. In this study, haptoglobin phenotypes were determined in 141 patients with peripheral arterial occlusive disease (PAOD) and compared to a reference population (n = 1000). The relative Hp1 allele frequency was decreased among PAOD patients (0.294 vs. 0.403 for the reference population, P < 0.01) due to an overrepresentation of the Hp 2-2 phenotype (50%, odds ratio 1.82 (95% C.I. 1.28-2.60), P < 0.001). This finding was even more pronounced in non-diabetic and in non-smoking PAOD patients (Hp1 allele frequencies: 0.265 and 0.228, respectively). Serum lipids, inflammatory parameters, and blood pressure levels were comparable among the Hp phenotypes, but serum levels of the antioxidant vitamin C were lower in Hp 2-2 patients than in patients with another phenotype (P < 0.05). In PAOD patients with severe atherosclerotic lesions, maximal walking distance of patients carrying a Hp 2-2 phenotype (225-525 m) exceeded that of other Hp phenotypes (50-242 m) (interquartile ranges) (P < 0.05). The findings demonstrate that, despite an increased risk for developing PAOD, the Hp 2-2 phenotype is associated with a longer maximal walking distance which might be attributed to the earlier reported in vitro angiogenic properties of the Hp 2-2 molecule.
触珠蛋白（Hp）2-2表型是冠状动脉粥样硬化的一个遗传风险因素。在本研究中，测定了141例外周动脉闭塞性疾病（PAOD）患者的触珠蛋白表型，并与一个参考人群（n = 1000）进行比较。PAOD患者中相对的Hp1等位基因频率降低（参考人群为0.403，PAOD患者为0.294，P < 0.01），原因是Hp 2-2表型的比例过高（50%，优势比1.82（95%置信区间1.28 - 2.60），P < 0.001）。这一发现在非糖尿病和非吸烟的PAOD患者中更为明显（Hp1等位基因频率分别为0.265和0.228）。不同Hp表型之间的血脂、炎症参数和血压水平相当，但Hp 2-2患者的抗氧化维生素C血清水平低于其他表型的患者（P < 0.05）。在有严重动脉粥样硬化病变的PAOD患者中，携带Hp 2-2表型的患者的最大行走距离（225 - 525米）超过了其他Hp表型的患者（50 - 242米）（四分位间距）（P < 0.05）。这些发现表明，尽管患PAOD的风险增加，但Hp 2-2表型与更长的最大行走距离相关，这可能归因于先前报道的Hp 2-2分子的体外血管生成特性。
