Heino A, Naukkarinen A, Pietiläinen T, Merasto M E, Törmälä P, Pohjonen T, Mäkelä E A
Department of Surgery, Kuopio University Hospital, Kuopio, Finland.
J Biomed Mater Res. 1999;48(5):596-601. doi: 10.1002/(sici)1097-4636(1999)48:5<596::aid-jbm2>3.0.co;2-s.
The suitability of a polyglycolic acid (PGA) membrane to fascial closure was tested in 40 rats. To induce collagen synthesis, a fascial strip from the vastus lateralis muscle was applied to the peritoneal side of the PGA membrane. A midline laparotomy was performed, and the incision was covered with the membrane fixed at the edges. The animals were sacrificed at 3, 6, 12, and 28 weeks, at which time macroscopical, histological, and electron microscopical findings, as well as the results of breaking force tests were evaluated. Fascial augmentation had no effect on the results. Ventral hernias were observed in 37.5% of the cases, half of which were observed after 6 weeks postoperatively. In one case, intestinal adhesions to the membrane were found. Inflammatory reaction during the follow-up was moderate and lasted up to 12 weeks. Breaking force decreased up to 6 weeks, after which it slightly increased without reaching the breaking force level of the control animals.
在40只大鼠身上测试了聚乙醇酸（PGA）膜用于筋膜闭合的适用性。为诱导胶原蛋白合成，将一条来自股外侧肌的筋膜条置于PGA膜的腹膜侧。进行中线剖腹手术，并用固定在边缘的膜覆盖切口。在3周、6周、12周和28周时处死动物，此时评估宏观、组织学和电子显微镜检查结果以及断裂力测试结果。筋膜增强对结果没有影响。在37.5%的病例中观察到腹疝，其中一半在术后6周后观察到。在1例中，发现肠与膜粘连。随访期间的炎症反应为中度，持续长达12周。断裂力在6周前下降，之后略有增加，但未达到对照动物的断裂力水平。
