Ashammakhi N, Mäkelä E A, Vihtonen K, Rokkanen P, Törmälä P
Department of Orthopedics and Traumatology, Helsinki University Central Hospital, Finland.
J Biomed Mater Res. 1995 Jun;29(6):687-94. doi: 10.1002/jbm.820290603.
A self-reinforced polyglycolide (SR-PGA) membrane has been developed recently by our research group and testing of it begun. To study the behavior of this membrane and its effect on cortical bone, 93 Wistar rats were operated on. SR-PGA membrane was applied around the rats' femoral diaphyses, either over the periosteum or directly over the bone, after periosteal stripping. In a control group no membrane was applied, but the femoral periosteum was stripped away. The rats were sacrificed 1, 3, 6, 12, 24, and 30 weeks postoperatively. Radiology, histology, oxytetracycline fluorescence labeling, microradiography, and planimetry were used to determine the outcome. A fibrous tissue capsule had formed around and replaced the membrane. SR-PGA membrane had a positive effect on new bone formation. Callus was frequently seen proximally and distally to the implant. Periosteal thickening occurred whether or not SR-PGA membrane was used. PGA fibers decreased in number and diameter continuously until they vanished by 30 weeks. No infections or adverse reactions were encountered. Accordingly, SR-PGA membrane is considered to be biocompatible and applicable in the treatment of cortical bone lesions such as comminuted fractures and defects.
我们研究小组最近研发出一种自增强聚乙交酯（SR-PGA）膜，并已开始对其进行测试。为研究该膜的性能及其对皮质骨的影响，对93只Wistar大鼠进行了手术。在大鼠股骨骨干周围，于骨膜剥离后，将SR-PGA膜置于骨膜上或直接置于骨上。对照组不放置膜，但剥离股骨骨膜。术后1、3、6、12、24和30周处死大鼠。采用放射学、组织学、土霉素荧光标记、显微放射摄影和平面测量法来确定结果。膜周围形成了纤维组织包膜并取代了该膜。SR-PGA膜对新骨形成有积极作用。在植入物近端和远端经常可见骨痂。无论是否使用SR-PGA膜，骨膜都会增厚。PGA纤维数量和直径持续减少，直至30周时消失。未出现感染或不良反应。因此，SR-PGA膜被认为具有生物相容性，可用于治疗粉碎性骨折和骨缺损等皮质骨病变。
