Seto W, Trope A E, Gow R M
Department of Pharmacy, The Hospital for Sick Children, Toronto, Ontario, Canada.
Ann Pharmacother. 1999 Sep;33(9):957-9. doi: 10.1345/aph.18359.
To determine the extent of removal of propafenone by continuous venovenous hemofiltration (CVVH) in a critically ill pediatric patient.
A three-year-old white-Japanese girl was admitted to the critical care unit following cardiac surgery. Her postoperative course was complicated by the development of junctional ectopic tachycardia, requiring propafenone, and acute renal failure, which necessitated the use of CVVH. The serum and ultrafiltrate concentrations of propafenone and its 5-hydroxy metabolite were measured to determine both total and CVVH clearance.
The data from this case report showed that propafenone was not significantly removed by CVVH. Furthermore, the total clearance of propafenone was not affected by the patient's renal or liver function impairment.
确定连续性静脉-静脉血液滤过（CVVH）对一名危重症儿科患者普罗帕酮的清除程度。
一名3岁的白种日本女孩心脏手术后入住重症监护病房。她的术后病程因交界性异位性心动过速（需使用普罗帕酮）及急性肾衰竭（需使用CVVH）而复杂化。测定普罗帕酮及其5-羟基代谢物的血清和超滤液浓度，以确定总清除率和CVVH清除率。
该病例报告的数据显示，CVVH对普罗帕酮的清除作用不显著。此外，普罗帕酮的总清除率不受患者肾功能或肝功能损害的影响。
