Pairleitner H, Steiner H, Hasenoehrl G, Staudach A
Department of Obstetrics and Gynecology, General Hospital Salzburg, Austria.
Ultrasound Obstet Gynecol. 1999 Aug;14(2):139-43. doi: 10.1046/j.1469-0705.1999.14020139.x.
To assess the feasibility of imaging low-velocity blood flow in adnexal masses by transvaginal three-dimensional power Doppler sonography, to analyze three-dimensional power Doppler sonography data sets with a new computer-assisted method and to test the reproducibility of the technique.
A commercially available 5-MHz Combison 530 ultrasound system was used to perform three-dimensional power Doppler sonography transvaginally. A cube (= volume of interest) was defined enclosing the vessels of the cyst and the Cartesian characteristics were stored on a hard disk. This cube was analyzed using specially designed software. Five indices representing vascularization (the vascularization index (VI) or blood flow (the flow index (FI)) or both (the vascularization-flow index (VFI)) were calculated. The intraobserver repeatability of cube definition and scan repetition was assessed using Hartley's test for homogeneous variances. Interobserver agreement was assessed by the Pearson correlation coefficient.
Imaging of vessels with low-velocity blood flow by three-dimensional power Doppler sonography and cube definition was possible in all adnexal massed studied. In some cases even induced non-vascular flow related to endometriosis was detected. The calculated F value with intraobserver repeated Cartesian file-saving ranged from 0 to 18.8, with intraobserver scan repetition from 4.74 to 24.8 for VI, FI 1, FI 2 and VFI 1; for VFI 2 the calculated F value was 64. The interobserver correlation coefficient ranged between 0.83 and 0.92 for VI, FI 1, FI 2 and VFI 1; for VFI 2 the correlation coefficient was less than 0.75.
Vessels with low-velocity blood flow can be imaged using three-dimensional power Doppler sonography. Induced non-vascular flow was detected in endometriotic cyst fluid. Three-dimensional power Doppler sonography combined with the cube method gave reproducible information for all indices except VFI 2. These indices might prove to be a new predictor in all fields of neoangiogenesis. The clinical relevance remains to be determined.
评估经阴道三维能量多普勒超声成像观察附件包块低速血流的可行性，用一种新的计算机辅助方法分析三维能量多普勒超声数据集，并测试该技术的可重复性。
使用市售的5兆赫Combison 530超声系统经阴道进行三维能量多普勒超声检查。定义一个立方体（感兴趣体积）以包围囊肿的血管，并将笛卡尔特征存储在硬盘上。使用专门设计的软件分析该立方体。计算代表血管化的五个指标（血管化指数（VI）或血流（血流指数（FI））或两者（血管化-血流指数（VFI））。使用Hartley齐性方差检验评估观察者内立方体定义和扫描重复的可重复性。通过Pearson相关系数评估观察者间的一致性。
在所有研究的附件包块中，三维能量多普勒超声和立方体定义均能对低速血流的血管进行成像。在某些情况下，甚至检测到与子宫内膜异位症相关的诱导性无血管血流。观察者内重复笛卡尔文件保存时计算的F值范围为0至18.8，观察者内扫描重复时，VI、FI 1、FI 2和VFI 1的F值范围为4.74至24.8；对于VFI 2，计算的F值为64。VI、FI 1、FI 2和VFI 1的观察者间相关系数范围在0.83至0.92之间；对于VFI 2，相关系数小于0.75。
使用三维能量多普勒超声可以对低速血流的血管进行成像。在子宫内膜异位囊肿液中检测到诱导性无血管血流。三维能量多普勒超声结合立方体方法为除VFI 2之外的所有指标提供了可重复的信息。这些指标可能成为新生血管形成所有领域的新预测指标。其临床相关性仍有待确定。
