Bomzon L, Wilton P B, Kew M C
Isr J Med Sci. 1978 Oct;14(10):1069-72.
The effect of dopamine hydrochloride on renal blood flow in bile duct ligated baboons was assessed using the 133Xe washout technique. Intrarenal infusions of dopamine in different concentrations did not significantly increase renal cortical blood flow. On the contrary, over the lower dose range, the normal dopamine-induced renal vasodilatation was abolished in the jaundiced state. An in vitro experiment that measured the perfusion pressure of an isolated rabbit kidney perfused with normal and jaundiced baboon plasma confirmed the in vivo results. These observations suggest that dopamine would not be of value in treating the renal failure that may develop in patients with obstructive jaundice.
采用¹³³Xe洗脱技术评估了盐酸多巴胺对胆管结扎狒狒肾血流的影响。不同浓度的多巴胺肾内输注并未显著增加肾皮质血流。相反，在较低剂量范围内，黄疸状态下正常多巴胺诱导的肾血管舒张作用消失。一项体外实验测量了用正常和黄疸狒狒血浆灌注的离体兔肾的灌注压，证实了体内实验结果。这些观察结果表明，多巴胺对治疗梗阻性黄疸患者可能发生的肾衰竭无价值。
